Sterol 14α-Demethylase from Trypanosomatidae Parasites as a Promising Target for Designing New Antiparasitic Agents

Strategies for the Synthesis of Mono- and Bis-Thionaphthoquinones

Trypanosomatidae household belongs to the Kinetoplastida order, which consists of compulsory parasites that have an effect on crops and all courses of vertebrates, particularly people and bugs. Among the heteroxenic parasites, Leishmania spp., Trypanosoma cruzi, and T. brucei are protozoa of most important curiosity for medicinal chemistry, being etiological brokers of Leishmaniasis, Chagas, and Sleep … Read more

Ohmic heating increases inactivation and morphological changes of Salmonella sp. and the formation of bioactive compounds in infant formula

Ohmic heating increases inactivation and morphological changes of Salmonella sp. and the formation of bioactive compounds in infant formula

The impact of ohmic heating (OH) (50, 55, and 60 °C, 6 V/cm) on the inactivation kinetics (Weibull mannequin) and morphological changes (scanning electron microscopy and stream cytometry) of Salmonella spp. in infant formula (IF) was evaluated. In addition, thermal load indicators (hydroxymethylfurfural and whey protein nitrogen index, HMF, and WPNI) and bioactive compounds (DPPH, complete phenolics, ACE, … Read more

Strategies for the Synthesis of Mono- and Bis-Thionaphthoquinones

Strategies for the Synthesis of Mono- and Bis-Thionaphthoquinones

The subclass of compounds which have the nucleus 1,4-naphthoquinone is the most various of the class of quinones, which have a big quantity of substances and a number of which have helpful purposes starting from medicinal chemistry to software in supplies with particular properties. The introduction of one or two substituents with the sulfur heteroatom in … Read more

Skeletal muscle metabolomics and blood biochemistry analysis reveal metabolic changes associated with dietary amino acid supplementation in dairy calves.

Skeletal muscle metabolomics and blood biochemistry analysis reveal metabolic changes associated with dietary amino acid supplementation in dairy calves.

The results of various amino acid (AA) supplementations of milk protein-based milk replacers in pre-ruminant calves from Three days to 7 weeks of age have been studied. Animals have been divided into four teams: Ctrl) Control group fed with milk protein-based milk replacer with out supplementation; GP) supplementation with 0.1% glycine and 0.3% proline; FY) … Read more