Coffee contains bioactivecompounds with anti-inflammatory properties, and its consumption may reduce c-reactive protein (CRP) levels, a biomarker of chronic inflammation. A previous meta-analysis reported no overall association between blood CRP level and coffee consumption by modeling the coffee consumption in categories, with substantial heterogeneity.
However, the coffee cup volume was not considered. We conducted a systematic review and dose-response meta-analysis investigating the association between coffee consumption and CRP levels reported in previous observational studies. A dose-response meta-analysis was conducted by mixed-effects meta-regression models using the volume of coffee consumed as metric.
Eleven studies from three continents were identified using the PubMed database, totaling 61,047 participants.
Three studies with the largest sample sizes observed a statistically significant association between coffee and CRP levels, which was inverse among European and United States (US) women and Japanese men (1.3%-5.5% decrease in CRP per 100 mL of coffee consumed) and positive among European men (2.2% increase).
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QP12351-50mg | EnQuireBio | 50mg | EUR 155 |
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QP12522-50mg | EnQuireBio | 50mg | EUR 3655 |
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QP10907-50mg | EnQuireBio | 50mg | EUR 1043 |
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QP10950-50mg | EnQuireBio | 50mg | EUR 553 |
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QP11102-50mg | EnQuireBio | 50mg | EUR 218 |
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QP13723-50mg | EnQuireBio | 50mg | EUR 363 |
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QP10565-50mg | EnQuireBio | 50mg | EUR 563 |
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QP10670-50mg | EnQuireBio | 50mg | EUR 1043 |
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QP12314-50mg | EnQuireBio | 50mg | EUR 201 |
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QP10897-50mg | EnQuireBio | 50mg | EUR 962 |
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QP10899-50mg | EnQuireBio | 50mg | EUR 563 |
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QP10544-50mg | EnQuireBio | 50mg | EUR 517 |
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60013 | Biotium | 50MG | EUR 210 |
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CA003-001 | GenDepot | 10ml | EUR 91 |
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60012 | Biotium | 50MG | EUR 153 |
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Description: CAS: 149647-78-9 |
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1036-50MG | Biovision | EUR 533 |
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1382-50mg | lumiprobe | 50 mg | EUR 921 |
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4119-50MG | Biovision | EUR 4220 |
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4216-50MG | Biovision | EUR 3470 |
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P008-50MG | Arbor Assays | 50MG | EUR 311 |
Description: CAS: 96017-59-3 |
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Description: CAS: 320-67-2 |
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Description: CAS: 2353-33-5 |
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Description: CAS: 433695-36-4 |
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P021-50MG | Arbor Assays | 50MG | EUR 1001 |
Description: CAS: 6754-58-1 |
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C017-50MG | TOKU-E | 50 mg | EUR 511 |
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C020210-50mg | Unibiotest | 50mg | EUR 6015 |
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C020213-50mg | Unibiotest | 50mg | EUR 2635 |
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C020220-50mg | Unibiotest | 50mg | EUR 6015 |
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C020233-50mg | Unibiotest | 50mg | EUR 2635 |
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C020234-50mg | Unibiotest | 50mg | EUR 2635 |
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C095-50MG | TOKU-E | 50 mg | EUR 144 |
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C145-50MG | TOKU-E | 50 mg | EUR 77 |
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M076-50MG | TOKU-E | 50 mg | EUR 523 |
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M077-50MG | TOKU-E | 50 mg | EUR 967 |
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N047-50MG | TOKU-E | 50 mg | EUR 138 |
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N050-50MG | TOKU-E | 50 mg | EUR 617 |
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E064-50MG | TOKU-E | 50 mg | EUR 112 |
![]() Epigallocatechin gallate |
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E065-50MG | TOKU-E | 50 mg | EUR 84 |
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A090-50MG | TOKU-E | 50 mg | EUR 127 |
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A099-50MG | TOKU-E | 50 mg | EUR 239 |
![]() Chicken IgY Protein |
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abx060688-50mg | Abbexa | 50 mg | EUR 551 |
![]() SL-01 |
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abx076822-50mg | Abbexa | 50 mg | EUR 272 |
![]() Leflunomide |
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abx076826-50mg | Abbexa | 50 mg | EUR 230 |
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abx076835-50mg | Abbexa | 50 mg | EUR 272 |
![]() Aztreonam |
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A017-50MG | TOKU-E | 50 mg | EUR 115 |
![]() Horseradish Peroxidase Antibody |
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abx022688-50mg | Abbexa | 50 mg | EUR 954 |
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abx022821-50mg | Abbexa | 50 mg | EUR 1052 |
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abx022828-50mg | Abbexa | 50 mg | EUR 857 |
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abx022830-50mg | Abbexa | 50 mg | EUR 857 |
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abx022832-50mg | Abbexa | 50 mg | EUR 1052 |
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abx022844-50mg | Abbexa | 50 mg | EUR 899 |
![]() (R)-(+)-7,7'-Bis(Diphenylphosphino)-2,2',3,3'-Tetrahydro-1,1'-Spirobiindane |
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abx180110-50mg | Abbexa | 50 mg | EUR 398 |
![]() Cafenstrole |
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abx185370-50mg | Abbexa | 50 mg | EUR 606 |
![]() (E)-3α-hydroxy-6-ethylidene-7-keto-5β-cholan-24-oic acid |
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abx186093-50mg | Abbexa | 50 mg | EUR 300 |
![]() dabigatran |
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abx186421-50mg | Abbexa | 50 mg | EUR 425 |
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abx188740-50mg | Abbexa | 50 mg | EUR 314 |
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Q002-50MG | TOKU-E | 50 mg | EUR 138 |
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R044-50MG | TOKU-E | 50mg | EUR 273 |
![]() Rocuronium Bromide |
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R045-50MG | TOKU-E | 50mg | EUR 102 |
![]() Telithromycin |
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T015-50MG | TOKU-E | 50 mg | EUR 291 |
![]() Tedizolid |
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T117-50MG | TOKU-E | 50mg | EUR 481 |
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T118-50MG | TOKU-E | 50mg | EUR 180 |
![]() Tipiracil Hydrochloride |
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T121-50MG | TOKU-E | 50mg | EUR 340 |
![]() Tolvaptan |
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T125-50MG | TOKU-E | 50mg | EUR 429 |
![]() Tenofovir Alafenamide |
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T128-50MG | TOKU-E | 50mg | EUR 144 |
![]() Vonoprazan fumarate |
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V029-50MG | TOKU-E | 50mg | EUR 782 |
![]() Ribonuclease A, DNase free |
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GE9871-50MG | Glentham Life Sciences | 50 mg | EUR 107 |
![]() N,N,N',N'-Tetrakis(2-pyridylmethyl)ethylenediamine |
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GK2289-50MG | Glentham Life Sciences | 50 mg | EUR 77 |
![]() SC-560 |
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GK2799-50MG | Glentham Life Sciences | 50 mg | EUR 349 |
![]() Aminopterin dihydrate |
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GK2974-50MG | Glentham Life Sciences | 50 mg | EUR 107 |
![]() Pravastatin sodium salt |
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GK3699-50MG | Glentham Life Sciences | 50 mg | EUR 110 |
![]() alpha-Mangostin |
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GK4316-50MG | Glentham Life Sciences | 50 mg | EUR 269 |
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GK4946-50MG | Glentham Life Sciences | 50 mg | EUR 200 |
![]() H-8 dihydrochloride |
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GK6037-50MG | Glentham Life Sciences | 50 mg | EUR 252 |
![]() Ro 61-8048 |
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GK6422-50MG | Glentham Life Sciences | 50 mg | EUR 548 |
![]() Cisapride monohydrate |
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GL0434-50MG | Glentham Life Sciences | 50 mg | EUR 229 |
![]() AdipoRon hydrochloride |
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GL0874-50MG | Glentham Life Sciences | 50 mg | EUR 459 |
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GL1129-50MG | Glentham Life Sciences | 50 mg | EUR 429 |
![]() 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one |
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GL1507-50MG | Glentham Life Sciences | 50 mg | EUR 321 |
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GL2255-50MG | Glentham Life Sciences | 50 mg | EUR 166 |
![]() WY-14643 |
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GL2940-50MG | Glentham Life Sciences | 50 mg | EUR 154 |
![]() Compound 112254 |
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GL3740-50MG | Glentham Life Sciences | 50 mg | EUR 459 |
![]() Cyclic Pifithrin-alpha hydrobromide |
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GL3913-50MG | Glentham Life Sciences | 50 mg | EUR 528 |
![]() PK 11195 |
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GL4857-50MG | Glentham Life Sciences | 50 mg | EUR 321 |
![]() MnTBAP chloride |
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GL5377-50MG | Glentham Life Sciences | 50 mg | EUR 154 |
![]() Shikonin |
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GL5964-50MG | Glentham Life Sciences | 50 mg | EUR 269 |
![]() AdipoRon |
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GL6438-50MG | Glentham Life Sciences | 50 mg | EUR 390 |
![]() Zerumbone |
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GL7258-50MG | Glentham Life Sciences | 50 mg | EUR 298 |
![]() GYY 4137 |
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GL7524-50MG | Glentham Life Sciences | 50 mg | EUR 321 |
![]() L-Alanyl-L-1-aminoethylphosphonic acid |
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GL8388-50MG | Glentham Life Sciences | 50 mg | EUR 158 |
![]() Corosolic acid |
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GL8496-50MG | Glentham Life Sciences | 50 mg | EUR 668 |
![]() MnTMPyP pentachloride |
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GL8780-50MG | Glentham Life Sciences | 50 mg | EUR 154 |
![]() Compound 112254 hydrochloride |
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GL8859-50MG | Glentham Life Sciences | 50 mg | EUR 459 |
![]() Ketanserin (+)-tartrate salt |
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GL9943-50MG | Glentham Life Sciences | 50 mg | EUR 172 |
![]() Phenyl b-D-thioglucopyranoside |
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GC0722-50MG | Glentham Life Sciences | 50 mg | EUR 70 |
![]() b-D-Allopyranose |
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GC0862-50MG | Glentham Life Sciences | 50 mg | EUR 61 |
![]() 5-Bromo-4-chloro-3-indolyl b-D-xylopyranoside |
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GC1526-50MG | Glentham Life Sciences | 50 mg | EUR 94 |
![]() Methyl N-acetyl-alpha-D-glucosaminide |
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GC2856-50MG | Glentham Life Sciences | 50 mg | EUR 142 |
![]() Maltohexaose |
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GC2935-50MG | Glentham Life Sciences | 50 mg | EUR 86 |
![]() 5-Bromo-4-chloro-3-indolyl b-D-galactopyranoside |
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GC3237-50MG | Glentham Life Sciences | 50 mg | EUR 54 |
![]() XTT sodium salt |
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GC5281-50MG | Glentham Life Sciences | 50 mg | EUR 142 |
![]() Spiperone hydrochloride |
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GE2928-50MG | Glentham Life Sciences | 50 mg | EUR 154 |
![]() Actinomycin D |
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GA0481-50MG | Glentham Life Sciences | 50 mg | EUR 174 |
![]() Ascomycin |
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GA1406-50MG | Glentham Life Sciences | 50 mg | EUR 285 |
![]() Mupirocin |
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GA2184-50MG | Glentham Life Sciences | 50 mg | EUR 82 |
![]() Flumethasone |
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GA2414-50MG | Glentham Life Sciences | 50 mg | EUR 70 |
![]() Telithromycin |
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GA2425-50MG | Glentham Life Sciences | 50 mg | EUR 150 |
![]() Linezolid |
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GA2609-50MG | Glentham Life Sciences | 50 mg | EUR 126 |
![]() Brefeldin A |
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GA2848-50MG | Glentham Life Sciences | 50 mg | EUR 389 |
![]() Doxorubicin hydrochloride |
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GA4969-50MG | Glentham Life Sciences | 50 mg | EUR 126 |
![]() Torezolid |
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GA5035-50MG | Glentham Life Sciences | 50 mg | EUR 90 |
![]() Pimaricin |
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GA5100-50MG | Glentham Life Sciences | 50 mg | EUR 50 |
![]() Ribavirin |
|||
GA5462-50MG | Glentham Life Sciences | 50 mg | EUR 62 |
![]() Phleomycin |
|||
GA6020-50MG | Glentham Life Sciences | 50 mg | EUR 269 |
![]() Biapenem |
|||
GA6808-50MG | Glentham Life Sciences | 50 mg | EUR 78 |
![]() Vinblastine sulfate |
|||
GA7194-50MG | Glentham Life Sciences | 50 mg | EUR 389 |
![]() Rapamycin |
|||
GA7417-50MG | Glentham Life Sciences | 50 mg | EUR 150 |
![]() Ceftibuten hydrate |
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GA7818-50MG | Glentham Life Sciences | 50 mg | EUR 120 |
![]() Mitomycin C |
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GA9147-50MG | Glentham Life Sciences | 50 mg | EUR 269 |
![]() Moxifloxacin hydrochloride |
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GA9781-50MG | Glentham Life Sciences | 50 mg | EUR 54 |
![]() Asiaticoside |
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GC7829-50MG | Glentham Life Sciences | 50 mg | EUR 344 |
Other studies showed no statistically significant associations. When all studies were combined in the dose-response meta-analysis, no statistically significant associations were observed among all participants or when stratified by gender or geographic location, reflecting the conflicting associations reported in the included studies. Further studies are warranted to explore these inconsistent associations.