Exosome-like nanoparticles (ELNs) are attracting interest as important vehicles of intercellular communication, both in prokaryotes and eukaryotes. Recently, dietary nanoparticles similar to mammalian exosomes have attracted attention for these features.
In particular they appear to be relevant in the modulation of several cellular processes as well as candidate carriers of bioactive molecules (proteins, lipids, and nucleic acids, including miRNAs) with therapeutic value. Herein, we investigated the cellular uptake of blueberry-derived ELNs (B-ELNs) by a human stabilized endothelial cell line (EA.hy926) and the ability of B-ELNs to modulate the expression of inflammatory genes as the response of tumor necrosis factor-α (TNF-α).
Our results indicate that 1) EA.hy926 cells internalize B-ELNs in a dose-dependent manner; 2) pretreatment with B-ELNs counters TNF-α-induced reactive oxygen species (ROS) generation and loss of cell viability and modulates the differential expression of 29 genes (fold change > 1.5) induced by TNF-α compared to control; 3) pathway analysis reveals their involvement in a total of 340 canonical pathways, 121 KEGG pathways, and 121 GO Biological processes;
and 4) the intersection between differentially expressed (DE) genes and miRNAs contained in B-ELNs unveils a set of candidate target genes, such as prostaglandin I2 synthase (PTGIS), mitogen-activated protein kinase 14 (MAPK14), and phosphodiesterase 7A (PDE7A), for ELNs-contained cargo.
—moraldo turkey
In conclusion, our study indicates that B-ELNs can be considered candidate therapeutic carriers of bioactivecompounds potentially able to protect vascular system against various stressors.
ERLENMEYER FLASK, 500 ML, PP |
4985P-500 |
CORNING |
6/pk |
EUR 64 |
Description: Reusable Plastics; Reusable Erl Flasks |
ERLENMEYER FLASK, 500 ML, PMP |
4990P-500 |
CORNING |
6/pk |
EUR 92 |
Description: Reusable Plastics; Reusable Erl Flasks |
WASH BOTTLE 500 ML, LDPE |
1300P-500 |
CORNING |
12/pk |
EUR 81 |
Description: Reusable Plastics; Resusable Bottles |
REAGENT BOTTLE,500 ML, PP |
1500P-500 |
CORNING |
10/pk |
EUR 62 |
Description: Reusable Plastics; Resusable Bottles |
DBCO-PEG-Biotin,500 |
HE048041-500-100mg |
Biochempeg |
100mg |
EUR 765 |
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
PLGA(50:50)?8K?-PEG-Mal,500 |
HE086022-500-500mg |
Biochempeg |
500mg |
EUR 765 |
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
Alkyne CPG modifier 500, 500 mg |
32860 |
Lumiprobe |
500 mg |
EUR 193 |
miRZip-500 anti-miR-500 microRNA construct |
MZIP500-PA-1 |
SBI |
Bacterial Streak |
EUR 684 |
|
FAM CPG 500, 6-isomer, 500 mg |
35760 |
Lumiprobe |
500 mg |
EUR 249 |
TFA-Amino modifier CPG 500, 500 mg |
31860 |
Lumiprobe |
500 mg |
EUR 193 |
Measuring Spoon 500 |
MSP05 |
Next Advance |
25pack |
EUR 123 |
Description: 500uL (0.5mL) measuring spoon. Ideal for aliquoting beads into tubes. |
ZeptoGel (500 mL) |
0801195 |
Zeptometrix |
500 mL |
EUR 327.68 |
|
Description: Please contact Gentaur in order to receive the datasheet of the product. |
Cellufine A-500 |
675980335 |
JNC America |
10 lt |
Ask for price |
Cellufine Q-500 |
675982335 |
JNC America |
10 lt |
Ask for price |
Cellufine C-500 |
675983335 |
JNC America |
10 lt |
Ask for price |
mPEG-SH,500 |
33-MF001003-500 |
Biochempeg |
|
|
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
mPEG-COOH?500 |
33-MF001017-500 |
Biochempeg |
|
|
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
mPEG-MAL,500 |
33-MF001022-500 |
Biochempeg |
|
|
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
500 ML SPINNER FLASK, 100 MM CENTRE NECK, 2 X 45 MM SIDEARMS |
4500-500 |
CORNING |
1/pk |
EUR 529 |
Description: Bioprocess Vessels; Spinner Flask 70 |
TUBE,MICENT,1.7ML,NAT,SC,NS,BK,500/500 |
3620 |
CORNING |
500/pk |
EUR 56 |
Description: Microcentrifuge Tubes; Snap Cap Tubes |
cleaning solution 500 ml |
B530 |
Consort |
ea |
EUR 30 |
500 G HEPES, POWDER |
61-034-RO |
CORNING |
500 g/pk |
EUR 146 |
Description: Media Catalog; Cell Culture Reagents |
PLASTIC CLAMP, 500 ML |
480151 |
CORNING |
1/pk |
EUR 70 |
Description: Lab Equipment; Constant Temperature Equipment |
MC Cellufine C-500 |
19-800-51 |
JNC America |
5 x 1 ml |
EUR 217 |
MC Cellufine C-500 |
19-800-55 |
JNC America |
5 x 5 ml |
EUR 345 |
MC Cellufine A-500 |
19-805-51 |
JNC America |
5 x 1 ml |
EUR 217 |
MC Cellufine A-500 |
19-805-55 |
JNC America |
5 x 5 ml |
EUR 345 |
MC Cellufine Q-500 |
19-907-51 |
JNC America |
5 x 1 ml |
EUR 217 |
MC Cellufine Q-500 |
19-907-55 |
JNC America |
5 x 5 ml |
EUR 345 |
MC Cellufine S-500 |
21-200-51 |
JNC America |
5 x 1 ml |
EUR 239 |
MC Cellufine S-500 |
21-200-55 |
JNC America |
5 x 5 ml |
EUR 420 |
HO-PEG-COOH,500 |
33-HE002017-500 |
Biochempeg |
|
|
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
SH-PEG-COOH,500 |
33-HE003017-500 |
Biochempeg |
|
|
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
HS-PEG-NHS,500 |
33-HE003023-500 |
Biochempeg |
|
|
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
NH2-PEG-COOH,500 |
33-HE005017-500 |
Biochempeg |
|
|
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
N3-PEG-OH,500 |
33-HE006002-500 |
Biochempeg |
|
|
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
N3-PEG-BIOTIN,500 |
33-HE006041-500 |
Biochempeg |
|
|
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
Biotin-PEG-COOH,500 |
33-HE041017-500 |
Biochempeg |
|
|
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
SH-PEG-SH,500 |
33-HO003003-500 |
Biochempeg |
|
|
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
AlKyne-PEG-AlKyne,500 |
33-HO007007-500 |
Biochempeg |
|
|
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
COOH-PEG-COOH,500 |
33-HO017017-500 |
Biochempeg |
|
|
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
SC-PEG-SC,500 |
33-HO023023-500 |
Biochempeg |
|
|
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
BMZERO™, 500 ml |
401 |
AthenaES |
500 ml |
EUR 105 |
EPM2™, 500 ml |
402 |
AthenaES |
500 ml |
EUR 107 |
HPC1™, 500 ml |
403 |
AthenaES |
500 ml |
EUR 110 |
Refolding Buffers - 500 ml |
612 |
AthenaES |
500 ml |
EUR 247 |
Augmedium™, Powder 500 |
124 |
AthenaES |
500 ml |
EUR 566 |
mmu-miR-500 Primers |
MPM00559 |
ABM |
150 ul / 10 uM |
EUR 121 |
rno-miR-500 Primers |
MP-r00247 |
ABM |
150 ul / 10 uM |
EUR 176 |
THPTA ligand, 500 mg |
H4050 |
Lumiprobe |
500 mg |
EUR 216 |
electrolyte 500 ml 4m licl |
B525 |
Consort |
ea |
EUR 121 |
Compact Balance, 500 grams, 115V |
BCM1302 |
Bio Basic |
1 pcs, 1 UNIT |
EUR 456.19 |
|
Precision Balance, 500 grams, 115V |
BCM1308 |
Bio Basic |
1 pcs, 1 UNIT |
EUR 1479.17 |
|
Measuring Spoon 500 RNase Free |
MSP05-RNA |
Next Advance |
10pack |
EUR 136 |
Description: 500uL (0.5mL) measuring spoon. Ideal for aliquoting beads into tubes. RNase free. |
500 ML HYBRIGRO SF™ |
40-215-CVR |
CORNING |
500 mL/pk |
EUR 200 |
Description: Specialty Media; Serum Free and Specialty Media |
500 G L-GLUTAMINE, POWDER |
61-030-RO |
CORNING |
500 g/pk |
EUR 199 |
Description: Media Catalog; Cell Culture Reagents |
500 G POLYSUCROSE 400, POWDER |
61-196-RO |
CORNING |
500 g/pk |
EUR 507 |
Description: Specialty Media; Insect Media Products |
500 G YEAST EXTRACT, POWDER |
61-231-RO |
CORNING |
500 g/pk |
EUR 178 |
Description: Media Catalog; Cell Culture Reagents |
BioRad CFX96, Megabase 500/1000 |
A28241L |
GeneOn |
5x25 pcs |
EUR 303 |
500 ML SODIUM CHLORIDE, 5M |
46-032-CV |
CORNING |
500 mL/pk |
EUR 90 |
Description: Media Catalog; Classical Media |
500 ML MCDB 131, 1X |
15-100-CV |
CORNING |
500 mL/pk |
EUR 132 |
Description: Media Catalog; Classical Media |
SharpProtein MarkerII unit: 500 µl |
FYP005-500UL |
Yeastern Biotech |
1 vial |
Ask for price |
Polyclonal CDC6 Antibody (aa400-500) |
APR02453G |
Leading Biology |
0.05ml |
EUR 484 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human CDC6 (aa400-500). This antibody is tested and proven to work in the following applications: |
Polyclonal ZBTB2 Antibody (aa450-500) |
APR02982G |
Leading Biology |
0.05mg |
EUR 484 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human ZBTB2 (aa450-500). This antibody is tested and proven to work in the following applications: |
Cal-500™, potassium salt |
20410 |
AAT Bioquest |
10x50 ug |
EUR 219 |
|
P4-8F™, 500 ml |
404 |
AthenaES |
500 ml |
EUR 107 |
LB*Booster™, Powder 500 |
126 |
AthenaES |
500 ml |
EUR 190 |
APF LB Lennox, 500 g |
132 |
AthenaES |
500 g |
EUR 107 |
mmu-miR-500-3p Primers |
MPM01366 |
ABM |
150 ul / 10 uM |
EUR 121 |