Coffee contains bioactivecompounds with anti-inflammatory properties, and its consumption may reduce c-reactive protein (CRP) levels, a biomarker of chronic inflammation. A previous meta-analysis reported no overall association between blood CRP level and coffee consumption by modeling the coffee consumption in categories, with substantial heterogeneity.
However, the coffee cup volume was not considered. We conducted a systematic review and dose-response meta-analysis investigating the association between coffee consumption and CRP levels reported in previous observational studies. A dose-response meta-analysis was conducted by mixed-effects meta-regression models using the volume of coffee consumed as metric.
Eleven studies from three continents were identified using the PubMed database, totaling 61,047 participants.
Three studies with the largest sample sizes observed a statistically significant association between coffee and CRP levels, which was inverse among European and United States (US) women and Japanese men (1.3%-5.5% decrease in CRP per 100 mL of coffee consumed) and positive among European men (2.2% increase).
![]() Recombinant other Exenatide Protein, Untagged, E.coli-50mg |
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QP11816-50mg | EnQuireBio | 50mg | EUR 2358.00 |
![]() Recombinant Bovine HTF Protein, Untagged, E.coli-50mg |
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QP12351-50mg | EnQuireBio | 50mg | EUR 155.00 |
![]() Recombinant E.coli LACTB Protein, Untagged, E.coli-50mg |
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QP12522-50mg | EnQuireBio | 50mg | EUR 3655.00 |
![]() Recombinant other Urease Protein, Untagged, E.coli-50mg |
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QP10907-50mg | EnQuireBio | 50mg | EUR 1043.00 |
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QP10950-50mg | EnQuireBio | 50mg | EUR 553.00 |
![]() Recombinant other Atosiban Protein, Untagged, E.coli-50mg |
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QP11102-50mg | EnQuireBio | 50mg | EUR 218.00 |
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QP13723-50mg | EnQuireBio | 50mg | EUR 363.00 |
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QP10565-50mg | EnQuireBio | 50mg | EUR 563.00 |
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QP10670-50mg | EnQuireBio | 50mg | EUR 1043.00 |
![]() SAHA (Vorinostat ) |
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P004-50MG | Arbor Assays | 50MG | EUR 119.00 |
Description: CAS: 149647-78-9 |
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QP12314-50mg | EnQuireBio | 50mg | EUR 201.00 |
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QP12317-50mg | EnQuireBio | 50mg | EUR 363.00 |
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QP10897-50mg | EnQuireBio | 50mg | EUR 962.00 |
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QP10899-50mg | EnQuireBio | 50mg | EUR 563.00 |
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QP10544-50mg | EnQuireBio | 50mg | EUR 517.00 |
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QP12316-50mg | EnQuireBio | 50mg | EUR 363.00 |
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QP11479-50mg | EnQuireBio | 50mg | EUR 926.00 |
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60013 | Biotium | 50MG | EUR 210.00 |
Description: Minimum order quantity: 1 unit of 50MG |
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00224 | Biotium | 25MG | EUR 207.00 |
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CA003-001 | GenDepot | 10ml | EUR 91.00 |
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60012 | Biotium | 50MG | EUR 153.00 |
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90083 | Biotium | 50MG | EUR 193.00 |
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MN800A-1 | SBI | 20 ml | EUR 127.00 |
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60014 | Biotium | 50MG | EUR 161.00 |
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DNL-P004 | Creative Diagnostics | 1 mL | EUR 949.00 |
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DNM-P004 | Creative Diagnostics | 10 mL | EUR 554.00 |
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88R-P004 | Fitzgerald | 1 liter | EUR 673.00 |
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P004-10G | TOKU-E | 10g | EUR 79.00 |
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P004-250MG | Arbor Assays | 250MG | EUR 283.00 |
Description: CAS: 149647-78-9 |
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P004-50G | TOKU-E | 50g | EUR 227.00 |
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WHM-P004 | Creative Diagnostics | 2 mL | EUR 1001.00 |
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A090-50MG | TOKU-E | 50 mg | EUR 127.00 |
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A099-50MG | TOKU-E | 50 mg | EUR 239.00 |
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1036-50MG | Biovision | EUR 533.00 |
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1039-50MG | Biovision | EUR 153.00 |
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1382-50mg | lumiprobe | 50 mg | EUR 921.00 |
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1476-50mg | lumiprobe | 50 mg | EUR 501.00 |
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1497-50mg | lumiprobe | 50 mg | EUR 921.00 |
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1512-50mg | lumiprobe | 50 mg | EUR 501.00 |
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4119-50MG | Biovision | EUR 4220.00 |
![]() R³ IGF-1, human recombinant |
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4216-50MG | Biovision | EUR 3470.00 |
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B004-50MG | TOKU-E | 50 mg | EUR 397.00 |
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B005-50MG | TOKU-E | 50 mg | EUR 575.00 |
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B012-50MG | TOKU-E | 50 mg | EUR 335.00 |
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B035-50MG | TOKU-E | 50 mg | EUR 72.00 |
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B053-50MG | TOKU-E | 50 mg | EUR 708.00 |
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B080-50MG | TOKU-E | 50mg | EUR 198.00 |
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D001-50MG | TOKU-E | 50 mg | EUR 400.00 |
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D024-50MG | TOKU-E | 50 mg | EUR 178.00 |
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D071-50MG | TOKU-E | 50 mg | EUR 186.00 |
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D078-50MG | TOKU-E | 50 mg | EUR 394.00 |
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D092-50MG | TOKU-E | 50mg | EUR 380.00 |
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E008-50MG | TOKU-E | 50 mg | EUR 277.00 |
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E039-50MG | TOKU-E | 50 mg | EUR 1082.00 |
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E058-50MG | TOKU-E | 50 mg | EUR 236.00 |
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E063-50MG | TOKU-E | 50 mg | EUR 252.00 |
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E064-50MG | TOKU-E | 50 mg | EUR 112.00 |
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E065-50MG | TOKU-E | 50 mg | EUR 84.00 |
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A017-50MG | TOKU-E | 50 mg | EUR 115.00 |
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abx022688-50mg | Abbexa | 50 mg | EUR 954.00 |
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abx022821-50mg | Abbexa | 50 mg | EUR 1052.00 |
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abx022828-50mg | Abbexa | 50 mg | EUR 857.00 |
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abx022830-50mg | Abbexa | 50 mg | EUR 857.00 |
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![]() Glucose Oxidase Antibody |
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abx022832-50mg | Abbexa | 50 mg | EUR 1052.00 |
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![]() Papain (Carica papaya) Antibody |
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abx022844-50mg | Abbexa | 50 mg | EUR 899.00 |
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![]() Irinotecan |
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abx188740-50mg | Abbexa | 50 mg | EUR 314.00 |
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![]() (R)-(+)-7,7'-Bis(Diphenylphosphino)-2,2',3,3'-Tetrahydro-1,1'-Spirobiindane |
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abx180110-50mg | Abbexa | 50 mg | EUR 398.00 |
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![]() Cafenstrole |
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abx185370-50mg | Abbexa | 50 mg | EUR 606.00 |
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![]() (E)-3α-hydroxy-6-ethylidene-7-keto-5β-cholan-24-oic acid |
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abx186093-50mg | Abbexa | 50 mg | EUR 300.00 |
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![]() dabigatran |
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abx186421-50mg | Abbexa | 50 mg | EUR 425.00 |
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![]() SL-01 |
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abx076822-50mg | Abbexa | 50 mg | EUR 272.00 |
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![]() Leflunomide |
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abx076826-50mg | Abbexa | 50 mg | EUR 230.00 |
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![]() Auranofin |
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abx076835-50mg | Abbexa | 50 mg | EUR 272.00 |
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![]() Chicken IgY Protein |
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abx060688-50mg | Abbexa | 50 mg | EUR 551.00 |
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![]() Cefepime |
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C008-50MG | TOKU-E | 50 mg | EUR 438.00 |
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C017-50MG | TOKU-E | 50 mg | EUR 511.00 |
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C020210-50mg | Unibiotest | 50mg | EUR 6015.00 |
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C020213-50mg | Unibiotest | 50mg | EUR 2635.00 |
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C020220-50mg | Unibiotest | 50mg | EUR 6015.00 |
![]() Rabbit Anti-Human IgG FC |
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C020221-50mg | Unibiotest | 50mg | EUR 6015.00 |
![]() Goat Anti-Human IgG Fab |
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C020233-50mg | Unibiotest | 50mg | EUR 2635.00 |
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C020234-50mg | Unibiotest | 50mg | EUR 2635.00 |
![]() Rabbit Anti-Human IgG (γ chain) |
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C020235-50mg | Unibiotest | 50mg | EUR 2635.00 |
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C020238-50mg | Unibiotest | 50mg | EUR 2635.00 |
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C020239-50mg | Unibiotest | 50mg | EUR 2635.00 |
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C020240-50mg | Unibiotest | 50mg | EUR 2635.00 |
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C020242-50mg | Unibiotest | 50mg | EUR 2635.00 |
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C035-50MG | TOKU-E | 50 mg | EUR 127.00 |
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C036-50MG | TOKU-E | 50 mg | EUR 119.00 |
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C070-50MG | TOKU-E | 50 mg | EUR 77.00 |
![]() Cefotiam Dihydrochloride |
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C095-50MG | TOKU-E | 50 mg | EUR 144.00 |
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C145-50MG | TOKU-E | 50 mg | EUR 77.00 |
![]() Camptothecin sodium |
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C146-50MG | TOKU-E | 50 mg | EUR 80.00 |
![]() Cidofovir dihydrate |
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C202-50MG | TOKU-E | 50 mg | EUR 219.00 |
![]() 4',6-Diamidino-2-phenylindole dihydrochloride |
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GT2414-50MG | Glentham Life Sciences | 50 mg | EUR 233.00 |
![]() 7-Diethylamino-3-(4-maleimidophenyl)-4-methylcoumarin |
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GT9922-50MG | Glentham Life Sciences | 50 mg | EUR 469.00 |
![]() Flavin adenine dinucleotide disodium salt hydrate |
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GV4061-50MG | Glentham Life Sciences | 50 mg | EUR 50.00 |
![]() Empagliflozin |
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GX6640-50MG | Glentham Life Sciences | 50 mg | EUR 528.00 |
![]() Flucloxacillin sodium |
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F009-50MG | TOKU-E | 50 mg | EUR 312.00 |
![]() Faropenem sodium |
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F016-50MG | TOKU-E | 50mg | EUR 242.00 |
![]() Fidaxomicin |
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F025-50MG | TOKU-E | 50 mg | EUR 105.00 |
![]() Ganciclovir |
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G002-50MG | TOKU-E | 50 mg | EUR 190.00 |
![]() Piperlongumine |
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GK8547-50MG | Glentham Life Sciences | 50 mg | EUR 223.00 |
![]() Bay 11-7082 |
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GK8638-50MG | Glentham Life Sciences | 50 mg | EUR 413.00 |
![]() Cisapride monohydrate |
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GL0434-50MG | Glentham Life Sciences | 50 mg | EUR 229.00 |
![]() AdipoRon hydrochloride |
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GL0874-50MG | Glentham Life Sciences | 50 mg | EUR 459.00 |
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GL1129-50MG | Glentham Life Sciences | 50 mg | EUR 429.00 |
![]() 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one |
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GL1507-50MG | Glentham Life Sciences | 50 mg | EUR 321.00 |
![]() MTSSL |
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GL1695-50MG | Glentham Life Sciences | 50 mg | EUR 436.00 |
![]() Tocainide hydrochloride |
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GL2205-50MG | Glentham Life Sciences | 50 mg | EUR 429.00 |
![]() Thonzonium bromide |
|||
GL2255-50MG | Glentham Life Sciences | 50 mg | EUR 166.00 |
![]() WY-14643 |
|||
GL2940-50MG | Glentham Life Sciences | 50 mg | EUR 154.00 |
![]() Compound 112254 |
|||
GL3740-50MG | Glentham Life Sciences | 50 mg | EUR 459.00 |
![]() Cyclic Pifithrin-alpha hydrobromide |
|||
GL3913-50MG | Glentham Life Sciences | 50 mg | EUR 528.00 |
![]() PK 11195 |
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GL4857-50MG | Glentham Life Sciences | 50 mg | EUR 321.00 |
![]() MnTBAP chloride |
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GL5377-50MG | Glentham Life Sciences | 50 mg | EUR 154.00 |
![]() Shikonin |
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GL5964-50MG | Glentham Life Sciences | 50 mg | EUR 269.00 |
![]() TOFA |
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GL6289-50MG | Glentham Life Sciences | 50 mg | EUR 198.00 |
![]() AdipoRon |
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GL6438-50MG | Glentham Life Sciences | 50 mg | EUR 390.00 |
![]() Epicoprostanol |
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GL6737-50MG | Glentham Life Sciences | 50 mg | EUR 137.00 |
![]() 4-Aminophenylphosphate sodium salt |
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GL6836-50MG | Glentham Life Sciences | 50 mg | EUR 252.00 |
![]() Zerumbone |
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GL7258-50MG | Glentham Life Sciences | 50 mg | EUR 298.00 |
![]() GYY 4137 |
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GL7524-50MG | Glentham Life Sciences | 50 mg | EUR 321.00 |
![]() L-Alanyl-L-1-aminoethylphosphonic acid |
|||
GL8388-50MG | Glentham Life Sciences | 50 mg | EUR 158.00 |
![]() Corosolic acid |
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GL8496-50MG | Glentham Life Sciences | 50 mg | EUR 668.00 |
![]() MnTMPyP pentachloride |
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GL8780-50MG | Glentham Life Sciences | 50 mg | EUR 154.00 |
![]() Compound 112254 hydrochloride |
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GL8859-50MG | Glentham Life Sciences | 50 mg | EUR 459.00 |
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GL9943-50MG | Glentham Life Sciences | 50 mg | EUR 172.00 |
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GN2518-50MG | Glentham Life Sciences | 50 mg | EUR 2582.00 |
![]() 5-(E)-(2-Bromovinyl)-2'-deoxyuridine |
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GN2626-50MG | Glentham Life Sciences | 50 mg | EUR 150.00 |
![]() 3'-O-Methylguanosine |
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GN3227-50MG | Glentham Life Sciences | 50 mg | EUR 190.00 |
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|||
GN7727-50MG | Glentham Life Sciences | 50 mg | EUR 269.00 |
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GN9104-50MG | Glentham Life Sciences | 50 mg | EUR 128.00 |
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GP0042-50MG | Glentham Life Sciences | 50 mg | EUR 150.00 |
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GP0138-50MG | Glentham Life Sciences | 50 mg | EUR 110.00 |
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GP0159-50MG | Glentham Life Sciences | 50 mg | EUR 86.00 |
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GP0555-50MG | Glentham Life Sciences | 50 mg | EUR 110.00 |
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GP0580-50MG | Glentham Life Sciences | 50 mg | EUR 628.00 |
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GP0706-50MG | Glentham Life Sciences | 50 mg | EUR 94.00 |
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GP0844-50MG | Glentham Life Sciences | 50 mg | EUR 778.00 |
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GP1522-50MG | Glentham Life Sciences | 50 mg | EUR 92.00 |
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GP2059-50MG | Glentham Life Sciences | 50 mg | EUR 309.00 |
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GP2111-50MG | Glentham Life Sciences | 50 mg | EUR 90.00 |
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GP2160-50MG | Glentham Life Sciences | 50 mg | EUR 102.00 |
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GP2886-50MG | Glentham Life Sciences | 50 mg | EUR 668.00 |
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GP2923-50MG | Glentham Life Sciences | 50 mg | EUR 1127.00 |
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GP3165-50MG | Glentham Life Sciences | 50 mg | EUR 269.00 |
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GP3424-50MG | Glentham Life Sciences | 50 mg | EUR 378.00 |
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GP3535-50MG | Glentham Life Sciences | 50 mg | EUR 158.00 |
![]() Ritonavir |
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GP3714-50MG | Glentham Life Sciences | 50 mg | EUR 75.00 |
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GP3849-50MG | Glentham Life Sciences | 50 mg | EUR 58.00 |
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GP3934-50MG | Glentham Life Sciences | 50 mg | EUR 66.00 |
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GP3972-50MG | Glentham Life Sciences | 50 mg | EUR 205.00 |
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GP4112-50MG | Glentham Life Sciences | 50 mg | EUR 102.00 |
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GP4188-50MG | Glentham Life Sciences | 50 mg | EUR 551.00 |
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GP4398-50MG | Glentham Life Sciences | 50 mg | EUR 62.00 |
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GP4647-50MG | Glentham Life Sciences | 50 mg | EUR 229.00 |
![]() Vinorelbine ditartrate |
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GP5205-50MG | Glentham Life Sciences | 50 mg | EUR 229.00 |
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|||
GP5216-50MG | Glentham Life Sciences | 50 mg | EUR 223.00 |
![]() Elacridar |
|||
GP5778-50MG | Glentham Life Sciences | 50 mg | EUR 357.00 |
![]() Zileuton |
|||
GP5873-50MG | Glentham Life Sciences | 50 mg | EUR 118.00 |
![]() Bosentan hydrate |
|||
GP5893-50MG | Glentham Life Sciences | 50 mg | EUR 130.00 |
![]() Carmofure |
|||
GP5925-50MG | Glentham Life Sciences | 50 mg | EUR 154.00 |
![]() Zafirlukast |
|||
GP6218-50MG | Glentham Life Sciences | 50 mg | EUR 110.00 |
![]() Tolazamide |
|||
GP6227-50MG | Glentham Life Sciences | 50 mg | EUR 237.00 |
![]() Lopinavir |
|||
GP6351-50MG | Glentham Life Sciences | 50 mg | EUR 70.00 |
![]() Acadesine |
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GP6637-50MG | Glentham Life Sciences | 50 mg | EUR 154.00 |
![]() Indinavir sulphate hydrate |
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GP6821-50MG | Glentham Life Sciences | 50 mg | EUR 126.00 |
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|||
GP6873-50MG | Glentham Life Sciences | 50 mg | EUR 110.00 |
![]() Curcumin, pure, 98% |
|||
GP7022-50MG | Glentham Life Sciences | 50 mg | EUR 160.00 |
![]() Saquinavir mesylate |
|||
GP7183-50MG | Glentham Life Sciences | 50 mg | EUR 150.00 |
![]() Levosimendan |
|||
GP7196-50MG | Glentham Life Sciences | 50 mg | EUR 110.00 |
![]() Nelfinavir mesylate |
|||
GP7332-50MG | Glentham Life Sciences | 50 mg | EUR 349.00 |
![]() Celastrol |
|||
GP7348-50MG | Glentham Life Sciences | 50 mg | EUR 620.00 |
![]() Apixaban |
|||
GP7497-50MG | Glentham Life Sciences | 50 mg | EUR 126.00 |
![]() Genistein |
|||
GP7710-50MG | Glentham Life Sciences | 50 mg | EUR 129.00 |
![]() Pranlukast hydrate |
|||
GP8160-50MG | Glentham Life Sciences | 50 mg | EUR 116.00 |
![]() Trilostane |
|||
GP8355-50MG | Glentham Life Sciences | 50 mg | EUR 166.00 |
![]() Nocodazole |
|||
GP8428-50MG | Glentham Life Sciences | 50 mg | EUR 390.00 |
![]() Vigabatrin |
|||
GP8547-50MG | Glentham Life Sciences | 50 mg | EUR 229.00 |
![]() Caspofungin acetate |
|||
GP8659-50MG | Glentham Life Sciences | 50 mg | EUR 221.00 |
![]() Metyrapone |
|||
GP8770-50MG | Glentham Life Sciences | 50 mg | EUR 118.00 |
![]() Cepharanthine |
|||
GP8908-50MG | Glentham Life Sciences | 50 mg | EUR 90.00 |
![]() Vecuronium bromide |
|||
GP9070-50MG | Glentham Life Sciences | 50 mg | EUR 90.00 |
![]() Orlistat |
|||
GP9255-50MG | Glentham Life Sciences | 50 mg | EUR 108.00 |
![]() D-Luciferin |
|||
GP9319-50MG | Glentham Life Sciences | 50 mg | EUR 150.00 |
![]() Cardiogreen |
|||
GT1409-50MG | Glentham Life Sciences | 50 mg | EUR 86.00 |
Other studies showed no statistically significant associations. When all studies were combined in the dose-response meta-analysis, no statistically significant associations were observed among all participants or when stratified by gender or geographic location, reflecting the conflicting associations reported in the included studies. Further studies are warranted to explore these inconsistent associations.